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For anyone not familiar with use case diagrams, here's a link to an easy-to-follow introduction to using them and another link to the Wikipedia entry for use case diagrams.
The discussion of technical interoperability will include, but not be limited to, whether to employ Web services with BPEL or ESB (or both) and business activity monitoring (BAM) tools.
The discussion of semantic interoperability will include, but not be limited to, whether to employ HL7 version 3 messages or CDA documents (or both).
Other topics such as service level agreements (SLA), key performance indicators (KPI), telemetry, and telemedicine will be included.